In 2020, the world was hit hard by the COVID-19 pandemic, forcing adjustments in the way societies function and demanding unprecedented efforts to reboot economies. The impacts of the pandemic on the lives, livelihoods and dignity of people everywhere are significant. Many countries now face major setbacks to progress toward the Sustainable Development Goals (SDGs). The pandemic has underscored how humankind is inextricably connected, and revealed multifaceted inequalities—with some who have access to care, services and opportunities, and some who are left behind. National authorities and communities across the world have struggled to respond to the crisis and to secure a sustainable and resilient recovery, with unprecedented support from the entire United Nations system, as well as by donors and partners, and by the scientific community and the private sector. Although more than seven billion doses of COVID-19 vaccines have been administered worldwide, a global vaccine gap threatens progress as the virus mutates and becomes more transmissible, and possibly more deadly. This document looks at the UN's Comprehensive Response to COVID-19 2021.